![]() ![]() The COVID-19 situation is still evolving rapidly, with alarming levels of spread in some geographic regions and disease severity, especially in the elderly and patients with pre-existing conditions ( Davies et al., 2020 Dong et al., 2020). The coronavirus disease 2019 (COVID-19) epidemic is caused by the human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ( Andersen et al., 2020 Bedford et al., 2020 Paules et al., 2020). ![]() Based on our findings, we propose the Roborovski dwarf hamster as a valuable model to examine the efficacy and safety of vaccine candidates and therapeutics, particularly for use in highly susceptible individuals. Particularly, only this species shows SARS-CoV-2-induced severe acute diffuse alveolar damage and hyaline microthrombi in the lungs, changes described in patients who succumbed to the infection but not reproduced in any experimentally infected animal. Here, we compare the susceptibilities of three dwarf hamster species ( Phodopus spp.) to SARS-CoV-2 and introduce the Roborovski dwarf hamster ( P. roborovskii) as a highly susceptible COVID-19 model with consistent and fulminant clinical signs. Different mammals are susceptible to SARS-CoV-2 however, few species examined so far develop robust clinical disease that mirrors severe human cases or allows testing of vaccines and drugs under conditions of severe disease. The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has precipitated an unprecedented and yet-unresolved health crisis worldwide. ![]()
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